Amino Acid
Published: Jul 17, 2023
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Updated: Sep 2, 2023
Written by Oseh Mathias
Founder, SpeechFit
Amino acids are organic compounds that serve as the building blocks of proteins [1]. They are composed of an amino group (-NH2), a carboxyl group (-COOH), and a side chain specific to each amino acid [2]. There are 20 commonly occurring amino acids that are essential for life on Earth [3].
The evolution of amino acids is thought to have occurred billions of years ago when simple organic molecules reacted under early Earth's conditions, leading to the formation of amino acids [4]. These amino acids then played a crucial role in the development of more complex organic compounds and eventually the emergence of life [5].
Amino acids play a significant role in the synthesis of neurotransmitters, which are chemical messengers that facilitate communication between nerve cells in the nervous system [6]. Several amino acids serve as precursors for neurotransmitter synthesis [7].
| Amino Acid | Role in Neurotransmitter Synthesis |
|---|---|
| Glutamate | Glutamate serves as a precursor for glutamate, the primary excitatory neurotransmitter in the central nervous system [8]. |
| GABA | GABA synthesized from glutamate and acts as the primary inhibitory neurotransmitter, regulating neuronal excitability [9]. |
| Glycine | Glycine acts as an inhibitory neurotransmitter primarily in the spinal cord and brainstem, regulating nerve signal transmission [10]. |
| Serine | Serine involved in the synthesis of neurotransmitters such as dopamine, norepinephrine, and epinephrine, regulating mood and other functions [11]. |
| Tryptophan | Tryptophan serves as a precursor for serotonin, a neurotransmitter involved in mood regulation, sleep-wake cycles, and appetite control [12]. |
| Tyrosine | Tyrosine used in the synthesis of neurotransmitters like dopamine, norepinephrine, and epinephrine, playing roles in motivation, attention, and stress responses [13]. |
These are just a few examples of amino acids and their roles in neurotransmitter synthesis. Amino acids, through their involvement in neurotransmitter production, are vital for proper functioning of the nervous system and play a fundamental role in various neurological processes.
Author
Oseh Mathias
SpeechFit Founder
Oseh is passionate about improving health and wellbeing outcomes for neurodiverse people and healthcare providers alike.
References
Nelson, D. L., & Cox, M. M. (2017). Lehninger Principles of Biochemistry. W. H. Freeman and Company.
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2002). Molecular Biology of the Cell. Garland Science.
Berg, J. M., Tymoczko, J. L., & Gatto, G. J. (2012). Biochemistry. W. H. Freeman and Company.
Sagan, C. (1970). Chemical evolution and the origin of life. Science, 170(3958), 1021-1026.
Deamer, D., & Damer, B. (2017). The hot spring hypothesis for an origin of life. Astrobiology, 17(8), 645-653.
Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of Neural Science. McGraw-Hill.
Cooper, J. R., Bloom, F. E., & Roth, R. H. (2003). The Biochemical Basis of Neuropharmacology. Oxford University Press.
Meldrum, B. S. (2000). Glutamate as a neurotransmitter in the brain: review of physiology and pathology. Journal of nutrition, 130(4), 1007S-1015S.
Gottesmann, C. (2002). GABA mechanisms and sleep. Neuroscience, 111(2), 231-239.
Legendre, P. (2001). The glycinergic inhibitory synapse. Cellular and Molecular Life Sciences CMLS, 58(5-6), 760-793.
Fernstrom, J. D. (2013). Large neutral amino acids: dietary effects on brain neurochemistry and function. Amino acids, 45(3), 419-430.
Richard, D. M., Dawes, M. A., Mathias, C. W., Acheson, A., Hill-Kapturczak, N., & Dougherty, D. M. (2009). L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. International journal of tryptophan research: IJTR, 2, 45–60.
Fernstrom, J. D., & Fernstrom, M. H. (2007). Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. The Journal of nutrition, 137(6), 1539S-1547S.